The world is a mask that hides the real world.
Thatâs what everybody suspects, though the world we see wonât let us dwell on it long.
The world has ways - more masks - of getting our attention.
The suspicion sneaks in now and again, between the cracks of everyday existenceâ¦the bird song dips, rises, dips, trails off into blue sky silence before the note that would reveal the shape of a melody that, somehow, would tie everything together, on the verge of unmasking the hidden armature that frames this sky, this tree, this bird, this quivering green leaf, jewels in a crown.â¦
As the song dies, the secret withdraws.
The tree is a mask.
The sky is a mask.
The quivering green leaf is a mask.
The song is a mask.
The singing bird is a mask.
Monday, December 19, 2005
human genome shaped (warped?) by "civilization"
Civilisation has left its mark on our genes
Bob Holmes, New Scientist, 19 December 2005
Darwin’s fingerprints can be found all over the human genome. A detailed look at human DNA has shown that a significant percentage of our genes have been shaped by natural selection in the past 50,000 years, probably in response to aspects of modern human culture such as the emergence of agriculture and the shift towards living in densely populated settlements.
One way to look for genes that have recently been changed by natural selection is to study mutations called single-nucleotide polymorphisms (SNPs) – single-letter differences in the genetic code. The trick is to look for pairs of SNPs that occur together more often than would be expected from the chance genetic reshuffling that inevitably happens down the generations.
Such correlations are known as linkage disequilibrium, and can occur when natural selection favours a particular variant of a gene, causing the SNPs nearby to be selected as well.
Robert Moyzis and his colleagues at the University of California, Irvine, US, searched for instances of linkage disequilibrium in a collection of 1.6 million SNPs scattered across all the human chromosomes. They then looked carefully at the instances they found to distinguish the consequences of natural selection from other phenomena, such as random inversions of chunks of DNA, which can disrupt normal genetic reshuffling.
This analysis suggested that around 1800 genes, or roughly 7% of the total in the human genome, have changed under the influence of natural selection within the past 50,000 years. A second analysis using a second SNP database gave similar results. That is roughly the same proportion of genes that were altered in maize when humans domesticated it from its wild ancestors.
“Domesticated” humans
Moyzis speculates that we may have similarly “domesticated” ourselves with the emergence of modern civilisation.
“One of the major things that has happened in the last 50,000 years is the development of culture,” he says. “By so radically and rapidly changing our environment through our culture, we’ve put new kinds of selection [pressures] on ourselves.”
Genes that aid protein metabolism – perhaps related to a change in diet with the dawn of agriculture – turn up unusually often in Moyzis’s list of recently selected genes. So do genes involved in resisting infections, which would be important in a species settling into more densely populated villages where diseases would spread more easily. Other selected genes include those involved in brain function, which could be important in the development of culture.
But the details of any such sweeping survey of the genome should be treated with caution, geneticists warn. Now that Moyzis has made a start on studying how the influence of modern human culture is written in our genes, other teams can see if similar results are produced by other analytical techniques, such as comparing human and chimp genomes.
Journal reference: Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.0509691102)
Related Articles
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Human brains are still evolving
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Evolution: Blink and you'll miss it
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Weblinks
Robert Moyzis, University of California
SNP fact sheet, Human Genome Project
Evolution special report, New Scientist
Bob Holmes, New Scientist, 19 December 2005
Darwin’s fingerprints can be found all over the human genome. A detailed look at human DNA has shown that a significant percentage of our genes have been shaped by natural selection in the past 50,000 years, probably in response to aspects of modern human culture such as the emergence of agriculture and the shift towards living in densely populated settlements.
One way to look for genes that have recently been changed by natural selection is to study mutations called single-nucleotide polymorphisms (SNPs) – single-letter differences in the genetic code. The trick is to look for pairs of SNPs that occur together more often than would be expected from the chance genetic reshuffling that inevitably happens down the generations.
Such correlations are known as linkage disequilibrium, and can occur when natural selection favours a particular variant of a gene, causing the SNPs nearby to be selected as well.
Robert Moyzis and his colleagues at the University of California, Irvine, US, searched for instances of linkage disequilibrium in a collection of 1.6 million SNPs scattered across all the human chromosomes. They then looked carefully at the instances they found to distinguish the consequences of natural selection from other phenomena, such as random inversions of chunks of DNA, which can disrupt normal genetic reshuffling.
This analysis suggested that around 1800 genes, or roughly 7% of the total in the human genome, have changed under the influence of natural selection within the past 50,000 years. A second analysis using a second SNP database gave similar results. That is roughly the same proportion of genes that were altered in maize when humans domesticated it from its wild ancestors.
“Domesticated” humans
Moyzis speculates that we may have similarly “domesticated” ourselves with the emergence of modern civilisation.
“One of the major things that has happened in the last 50,000 years is the development of culture,” he says. “By so radically and rapidly changing our environment through our culture, we’ve put new kinds of selection [pressures] on ourselves.”
Genes that aid protein metabolism – perhaps related to a change in diet with the dawn of agriculture – turn up unusually often in Moyzis’s list of recently selected genes. So do genes involved in resisting infections, which would be important in a species settling into more densely populated villages where diseases would spread more easily. Other selected genes include those involved in brain function, which could be important in the development of culture.
But the details of any such sweeping survey of the genome should be treated with caution, geneticists warn. Now that Moyzis has made a start on studying how the influence of modern human culture is written in our genes, other teams can see if similar results are produced by other analytical techniques, such as comparing human and chimp genomes.
Journal reference: Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.0509691102)
Related Articles
Can biology do better than faith?
02 November 2005
Human brains are still evolving
17 September 2005
Evolution: Blink and you'll miss it
09 July 2005
Weblinks
Robert Moyzis, University of California
SNP fact sheet, Human Genome Project
Evolution special report, New Scientist
