The world is a mask that hides the real world.
That’s what everybody suspects, though the world we see won’t let us dwell on it long.
The world has ways - more masks - of getting our attention.
The suspicion sneaks in now and again, between the cracks of everyday existence…the bird song dips, rises, dips, trails off into blue sky silence before the note that would reveal the shape of a melody that, somehow, would tie everything together, on the verge of unmasking the hidden armature that frames this sky, this tree, this bird, this quivering green leaf, jewels in a crown.…
As the song dies, the secret withdraws.
The tree is a mask.
The sky is a mask.
The quivering green leaf is a mask.
The song is a mask.
The singing bird is a mask.


Wednesday, May 11, 2005

chimerical chimeras

....Nothing to look at here folks, move along please, absolutely nothing at all. Move along now please, absolutely nothing, nothing at all....

It's Science, Not a Freak Show, New York Times, editorial, 11 May 2005
The latest focus of apprehension over the headlong rush of biotechnology involves the creation of animal-human hybrids, known as chimeras. Distinguished groups of ethicists and scientists have been pondering what steps should be taken, if any, to head off the nightmarish possibility of a human brain's becoming trapped inside an animal form, silently screaming, "Let me out," or a human embryo's being gestated by mice. It is fascinating - some would say terrifying - to contemplate, but these weird, far-out possibilities should not distract us from welcoming more mundane experiments with chimeras that will be needed to advance science.

We are already partly down the path of mixing human and animal cells or organs. Although it once seemed odd and unsettling, no one worries much anymore about transplanting pig valves into human hearts or human fetal tissue into mice. The key reason may be that these manipulations don't visibly change the fundamental nature of either the human or the animal. People become much more concerned when they think a transplant may alter the mind or appearance of the recipient. Nobody seems eager for a human with an animal tail, or an animal with human hands or sensibilities.

Fortunately, real-world scientists have much more prosaic experiments in mind. In the superheated area of embryonic stem cell research, for example, they want to put lots of human-brain stem cells into mice to see how they perform in a real body as opposed to a laboratory culture, possibly shedding light on how to treat neurological diseases. The researchers appear to be proceeding cautiously, and the scientific community is erecting ethical barriers to guide such research. This is hardly a freak show. If stem cell therapies pan out, the Food and Drug Administration will almost certainly require animal experiments before they can approved for the public. Research that some consider scary today may be required by regulators tomorrow.






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